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DS-70

Chemical Structure : DS-70

CAS No.: 2733814-97-4

DS-70 (α4 integrin inhibitor DS-70, DS70)

Catalog No.: PC-35545Not For Human Use, Lab Use Only.

DS-70 (α4 integrin inhibitor DS-70) is a novel potent α/β- peptidomimetic antagonist of α4 integrin, binds to integrin α4β1 with nanomolar affinity.

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    Biological Activity

    DS-70 (α4 integrin inhibitor DS-70) is a novel potent α/β- peptidomimetic antagonist of α4 integrin, binds to integrin α4β1 with nanomolar affinity.
    DS-70 prevents the adhesion of α4 integrin-expressing cells, antagonizes VCAM-1-mediated degranulation of mast cells and eosinophils and ERK 1/2 phosphorylation.
    DS-70  does not inhibit cell adhesion mediated by the leukocyte integrins aLb2 and aMb2 or by the Arg-GlyAsp (RGD)-binding integrins α5β1, αVβ3, αVβ5, αVβ6 and αIIbβ3.
    DS-70 dose-dependently reduces the clinical symptoms of allergic conjunctivitis, conjunctival α4 integrin expression and conjunctival levels of chemokines and cytokines in ovalbumin-sensitized guinea pigs.

    Physicochemical Properties

    M.Wt 438.484
    Formula C23H26N4O5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (S)-(1-(2-(4-(3-(o-tolyl)ureido)phenyl)acetyl)pyrrolidine-3-carbonyl)glycine

    References

    1. Dattoli SD, et al. Br J Pharmacol. 2018 Jul 26. doi: 10.1111/bph.14458.

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