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Chemical Structure : DS-9300
Catalog No.: PC-49530Not For Human Use, Lab Use Only.
DS-9300 (DS9300) is a highly potent, selective and orally active EP300/CBP histone acetyltransferase (HAT) inhibitor with IC50 of 28 nM, inhibits cellular acetylation of histone H3K27 (H3K27Ac) with IC50 of 54 nM.
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DS-9300 (DS9300) is a highly potent, selective and orally active EP300/CBP histone acetyltransferase (HAT) inhibitor with IC50 of 28 nM, inhibits cellular acetylation of histone H3K27 (H3K27Ac) with IC50 of 54 nM.
DS-9300 inhibits VCaP cell growth with GI50 of 0.6 nM, and DS-9300 (3 mg/kg, once daily, oral) demonstrated potent antitumor effects in a castrated VCaP xenograft mouse model without significant body weight loss.
| M.Wt | 501.510 | |
| Formula | C25H26F3N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kanada R, et al. J Med Chem. 2022 Dec 26. doi: 10.1021/acs.jmedchem.2c01641.
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