Catalog No.: PC-72232Not For Human Use, Lab Use Only.
DS12881479 (DS 12881479) is a novel potent, selective inhibitor of MAPK-interacting kinase 1 (Mnk1) with IC50 of 21 nM, stabilizes the autoinhibited state of Mnk1.
DS12881479 (DS 12881479) is a novel potent, selective inhibitor of MAPK-interacting kinase 1 (Mnk1) with IC50 of 21 nM, stabilizes the autoinhibited state of Mnk1.
DS12881479 exhibits its potent inhibitory activity mainly by interacting with inactive Mnk1 (active Mnk1 IC50=416 nM).
DS12881479 has good selectivity for Mnk1 against a panel 48 active kinase, only two kinases, FLT3 and DYRK1a (>50% inhibition at 5 uM).
