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Chemical Structure : DS12881479
CAS No.: 2373065-59-7
Catalog No.: PC-72232Not For Human Use, Lab Use Only.
DS12881479 (DS 12881479) is a novel potent, selective inhibitor of MAPK-interacting kinase 1 (Mnk1) with IC50 of 21 nM, stabilizes the autoinhibited state of Mnk1.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 1 mg | $188 | In stock | |
| 5 mg | $398 | In stock | |
| 10 mg | $598 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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DS12881479 (DS 12881479) is a novel potent, selective inhibitor of MAPK-interacting kinase 1 (Mnk1) with IC50 of 21 nM, stabilizes the autoinhibited state of Mnk1.
DS12881479 exhibits its potent inhibitory activity mainly by interacting with inactive Mnk1 (active Mnk1 IC50=416 nM).
DS12881479 has good selectivity for Mnk1 against a panel 48 active kinase, only two kinases, FLT3 and DYRK1a (>50% inhibition at 5 uM).
| M.Wt | 301.408 | |
| Formula | C16H19N3OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-Methyl-N-(5-phenylthiazol-2-yl)piperidine-4-carboxamide |
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1. Yumi Matsui, et al. Acta Crystallogr F Struct Biol Commun. 2018 Mar 1;74(Pt 3):156-160.
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