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Chemical Structure : DS16570511
CAS No.: 2446154-84-1
Catalog No.: PC-61012Not For Human Use, Lab Use Only.
DS16570511 is a cell-permeable inhibitor of the mitochondrial calcium uniporter (MCU) that inhibits serum-induced mitochondrial Ca2+ influx in HEK293A cells with IC50 of 7 uM.
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| 5 mg | $388 | In stock | |
| 10 mg | $588 | In stock | |
| 25 mg | $898 | In stock | |
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DS16570511 is a cell-permeable inhibitor of the mitochondrial calcium uniporter (MCU) that inhibits serum-induced mitochondrial Ca2+ influx in HEK293A cells with IC50 of 7 uM.
DS16570511 blocks the MCU- or MICU1-dependent increases of Ca2+ influx, blocks the Ca2+ uptake activity of the pig heart mitochondria with IC50 of 15 uM.
DS16570511 also blocks mitochondrial Ca2+ overload in a Langendorff perfused beating rat heart, increases cardiac contractility without affecting heart rate in the perfused heart.
| M.Wt | 562.447 | |
| Formula | C30H25Cl2N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-[3-(3-{[3-(2,6-Dichloro-phenyl)-5-methyl-isoxazol-4-ylmethyl]-amino}-benzoyl)-indol-1-yl]-butyric acid |
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1. Kon N, et al. Cell Death Discov. 2017 Jul 17;3:17045.
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