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DS17701585

Chemical Structure : DS17701585

CAS No.: 2983027-66-1

DS17701585 (DS 17701585)

Catalog No.: PC-38649Not For Human Use, Lab Use Only.

DS17701585 is a novel potent, highly selective EP300/CBP histone acetyltransferase inhibitor with IC50 of 0.15 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    DS17701585 is a novel potent, highly selective EP300/CBP histone acetyltransferase inhibitor with IC50 of 0.15 uM.
    DS17701585 shows dose-dependent inhibition of SRY-box transcription factor 2 (SOX2) mRNA expression in a human lung squamous cell carcinoma cell line LK2-xenografted mouse model.

    Physicochemical Properties

    M.Wt 482.555
    Formula C24H26N4O5S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (S)-N-(1H-indazol-4-yl)-3-(1-(4-methoxyphenyl)cyclopentane-1-carbonyl)thiazolidine-4-carboxamide 1,1-dioxide

    References

    1. Ryutaro Kanada, et al. Bioorg Med Chem Lett. 2022 Jun 15;66:128726.

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