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DS43260857

Chemical Structure : DS43260857

CAS No.: 1612158-07-2

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DS43260857 (DS 43260857, DS-43260857)

Catalog No.: PC-20850Not For Human Use, Lab Use Only.

DS43260857 is a potent, selective NaV1.7 inhibitor with IC50 of 15 nM (hNaV1.7), shows 440-fold and 930-fold selectivity over hNaV1.1 and hNaV1.5, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    DS43260857 is a potent, selective NaV1.7 inhibitor with IC50 of 15 nM (hNaV1.7), shows 440-fold and 930-fold selectivity over hNaV1.1 and hNaV1.5, respectively.
    DS43260857 potently inhibits mouse NaV1.7 (mNaV1.7) with IC50 of 61 nM.
    DS43260857 demonstrates highly potent in vitro activities against human and mouse NaV1.7 with an excellent PK profile and demonstrated potent in vivo efficacy in PSL mice at 1 mg/kg.

    Physicochemical Properties

    M.Wt 423.41
    Formula C19H16F3N3O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(cyclopropylsulfonyl)-3-methyl-1-(5-(trifluoromethyl)pyridin-3-yl)-1H-indole-5-carboxamide

    References

    1. Narayan Karanjule, et al. ACS Med Chem Lett. 2023 May 24;14(6):788-793.

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