DS43260857 | NaV1.7 inhibitor | Probechem Biochemicals

Chemical Structure : DS43260857

DS43260857 (DS 43260857)

Catalog No.: PC-20850Not For Human Use, Lab Use Only.

DS43260857 is a potent, selective NaV1.7 inhibitor with IC50 of 15 nM (hNaV1.7), shows 440-fold and 930-fold selectivity over hNaV1.1 and hNaV1.5, respectively.

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Biological Activity

DS43260857 is a potent, selective NaV1.7 inhibitor with IC50 of 15 nM (hNaV1.7), shows 440-fold and 930-fold selectivity over hNaV1.1 and hNaV1.5, respectively.
DS43260857 potently inhibits mouse NaV1.7 (mNaV1.7) with IC50 of 61 nM.
DS43260857 demonstrates highly potent in vitro activities against human and mouse NaV1.7 with an excellent PK profile and demonstrated potent in vivo efficacy in PSL mice at 1 mg/kg.

Physicochemical Properties

M.Wt	423.41
Formula	C19H16F3N3O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(NS(C1CC1)(=O)=O)C2=CC=C(N(C3=CC(C(F)(F)F)=CN=C3)C=C4C)C4=C2

References

1. Narayan Karanjule, et al. ACS Med. Chem. Lett. 2023.

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DS43260857 (DS 43260857)

Biological Activity

Physicochemical Properties

References

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