Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : DSR-141562
CAS No.: 2007975-22-4
Catalog No.: PC-47111Not For Human Use, Lab Use Only.
DSR-141562 (DSR141562) is a potent, selective orally available and brain-penetrant phosphodiesterase 1 (PDE1) inhibitor with IC50 of 97.6, 43.9 and 431.8 nM for human PDE1A, PDE1B and PDE1C, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $298 | In stock | |
| 10 mg | $488 | In stock | |
| 25 mg | Get quote | ||
| 50 mg | Get quote | ||
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
DSR-141562 (DSR141562) is a potent, selective orally available and brain-penetrant phosphodiesterase 1 (PDE1) inhibitor with IC50 of 97.6, 43.9 and 431.8 nM for human PDE1A, PDE1B and PDE1C, respectively.
DSR-141562 shows 2.2- and 9.8-fold selectivity for PDE1B over PDE1A and PDE1C, but has no effect or only weak inhibitory effects for other PDE families (PDE2A, IC50=2480 nM).
DSR-141562 elevated the tissue level of cGMP in mouse striatum and frontal cortex, as well as cGMP level in the monkey CSF.
DSR-141562 demonstrated efficacy in animal models for schizophrenia, DSR-141562 (3–30 mg/kg) inhibited methamphetamine-induced locomotor hyperactivity in rats.
| M.Wt | 414.429 | |
| Formula | C19H25F3N4O3 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
3-methyl-7-(tetrahydro-2H-pyran-4-yl)-2-{[trans-4-(trifluoromethyl)cyclohexyl]-methoxy}imidazo[5,1-f][1,2,4]triazin-4(3H)-one |
|
1. Enomoto T, et al. J Pharmacol Exp Ther. 2019 Dec;371(3):692-702.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
