Catalog No.: PC-47111Not For Human Use, Lab Use Only.
DSR-141562 (DSR141562) is a potent, selective orally available and brain-penetrant phosphodiesterase 1 (PDE1) inhibitor with IC50 of 97.6, 43.9 and 431.8 nM for human PDE1A, PDE1B and PDE1C, respectively.
DSR-141562 (DSR141562) is a potent, selective orally available and brain-penetrant phosphodiesterase 1 (PDE1) inhibitor with IC50 of 97.6, 43.9 and 431.8 nM for human PDE1A, PDE1B and PDE1C, respectively.
DSR-141562 shows 2.2- and 9.8-fold selectivity for PDE1B over PDE1A and PDE1C, but has no effect or only weak inhibitory effects for other PDE families (PDE2A, IC50=2480 nM).
DSR-141562 elevated the tissue level of cGMP in mouse striatum and frontal cortex, as well as cGMP level in the monkey CSF.
DSR-141562 demonstrated efficacy in animal models for schizophrenia, DSR-141562 (3–30 mg/kg) inhibited methamphetamine-induced locomotor hyperactivity in rats.
