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DSR-71167

Chemical Structure : DSR-71167

CAS No.: 1355687-91-0

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DSR-71167 (DSR 71167, DSR71167)

Catalog No.: PC-60751Not For Human Use, Lab Use Only.

DSR-71167 is a potent, selective mineralocorticoid receptor (MR) antagonist (IC50=0.26 uM) with carbonic anhydrase inhibitory activity (IC50=19 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    DSR-71167 is a potent, selective mineralocorticoid receptor (MR) antagonist (IC50=0.26 uM) with carbonic anhydrase inhibitory activity (IC50=19 uM).
    DSR-71167 displays >42-fold selectivity over other steroid receptors (AR, PR and GR).
    DSR-71167 dose-dependently increases urinary excretion of sodium in deoxycorticosterone acetate-treated rats without elevating serum levels of potassium, but not the DSR-30192 (NO carbonic anhydrase inhibitory activity, IC50>100 uM).
    DSR-71167 shows antihypertensive effects in rats.

    Physicochemical Properties

    M.Wt 529.959
    Formula C23H23ClF3N3O4S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-([(2,2-difluoroethyl)amino]methyl)-2'-fluoro-N-(3-methoxy-4-sulfamoylphenyl)biphenyl-4-carboxamide hydrochloride

    References

    1. Nariai T, et al. J Pharmacol Exp Ther. 2015 Jul;354(1):2-9.

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