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Chemical Structure : DSR-71167
Catalog No.: PC-60751Not For Human Use, Lab Use Only.
DSR-71167 is a potent, selective mineralocorticoid receptor (MR) antagonist (IC50=0.26 uM) with carbonic anhydrase inhibitory activity (IC50=19 uM).
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DSR-71167 is a potent, selective mineralocorticoid receptor (MR) antagonist (IC50=0.26 uM) with carbonic anhydrase inhibitory activity (IC50=19 uM).
DSR-71167 displays >42-fold selectivity over other steroid receptors (AR, PR and GR).
DSR-71167 dose-dependently increases urinary excretion of sodium in deoxycorticosterone acetate-treated rats without elevating serum levels of potassium, but not the DSR-30192 (NO carbonic anhydrase inhibitory activity, IC50>100 uM).
DSR-71167 shows antihypertensive effects in rats.
| M.Wt | 529.959 | |
| Formula | C23H23ClF3N3O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Nariai T, et al. J Pharmacol Exp Ther. 2015 Jul;354(1):2-9.
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