Chemical Structure : DW18134
CAS No.:
2626988-87-0
DW18134
(DW-18134, DW 18134)
Catalog No.: PC-22241Not For Human Use, Lab Use Only.
DW18134 is a potent, selective IRAK4 kinase inhibitor with IC50 of 11.2 nM, inhibits the IRAK4-induced activation of NF-κB signaling.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
DW18134 is a potent, selective IRAK4 kinase inhibitor with IC50 of 11.2 nM, inhibits the IRAK4-induced activation of NF-κB signaling.
DW18134 inhibited TNF-α and IL-6 secretion in a dose-dependent manner in PCM and RAW264.7 cells, did not affect the proliferation of macrophages.
DW18134 (15 mg/kg and 30 mg/kg, i.p.) ameliorated inflammatory phenotype and acute tissue damage in LPS-induced peritonitis mice.
DW18134 reduced macrophage infiltration and pro-inflammatory gene expression and abrogated IRAK4 signaling pathway activation in LPS-induced peritonitis mice.
DW18134 (2 mg/kg, i.p.) ameliorated symptoms and reduced intestinal pathological damage in mice with DSS-induced experimental colitis.
Physicochemical Properties
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M.Wt
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427.46
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Formula
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C24H21N5O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-(2-aminopyridin-4-yl)-N-(2,2-dimethyl-6-(pyridin-4-yl)-2,3-dihydrobenzofuran-5-yl)oxazole-4-carboxamide
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References
1. Yuqing Huang, et al. Molecules. 2024 Apr 16;29(8):1803.
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