Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : DW18134
Catalog No.: PC-22241Not For Human Use, Lab Use Only.
DW18134 is a potent, selective IRAK4 kinase inhibitor with IC50 of 11.2 nM, inhibits the IRAK4-induced activation of NF-κB signaling.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
DW18134 is a potent, selective IRAK4 kinase inhibitor with IC50 of 11.2 nM, inhibits the IRAK4-induced activation of NF-κB signaling.
DW18134 inhibited TNF-α and IL-6 secretion in a dose-dependent manner in PCM and RAW264.7 cells, did not affect the proliferation of macrophages.
DW18134 (15 mg/kg and 30 mg/kg, i.p.) ameliorated inflammatory phenotype and acute tissue damage in LPS-induced peritonitis mice.
DW18134 reduced macrophage infiltration and pro-inflammatory gene expression and abrogated IRAK4 signaling pathway activation in LPS-induced peritonitis mice.
DW18134 (2 mg/kg, i.p.) ameliorated symptoms and reduced intestinal pathological damage in mice with DSS-induced experimental colitis.
| M.Wt | 427.46 | |
| Formula | C24H21N5O3 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Yuqing Huang, et al. Molecules. 2024 Apr 16;29(8):1803.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
