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Chemical Structure : DWL-4-140
Catalog No.: PC-20989Not For Human Use, Lab Use Only.
DWL-4-140 is a small molecule inhibitor of cyclized nucleotide-binding domain (CBD) of STING, selectively inhibits DNA-mediated IFNβ responses with IC50 of 617 nM.
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DWL-4-140 is a small molecule inhibitor of cyclized nucleotide-binding domain (CBD) of STING, selectively inhibits DNA-mediated IFNβ responses with IC50 of 617 nM.
DWL-4-140 interacts with the mmSTING CBD and inhibits the formation of STING multimeric complexes.
DWL-4-140 inhibits STING recruitment to TBK1.
DWL-4-140 suppresses the spontaneous expression of interferon-stimulated genes (ISGs) in Trex1−/− mice.
DWL-4-140 (5 mg/kg) effectively alleviates the lupus-like phenotype in Trex1-/- mice.
| M.Wt | 568.71 | |
| Formula | C32H28N2O4S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hekang Du, et al. Biomed Pharmacother. 2023 Jul 20;165:115188.
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