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DWL-4-140

Chemical Structure : DWL-4-140

CAS No.:

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DWL-4-140

Catalog No.: PC-20989Not For Human Use, Lab Use Only.

DWL-4-140 is a small molecule inhibitor of cyclized nucleotide-binding domain (CBD) of STING, selectively inhibits DNA-mediated IFNβ responses with IC50 of 617 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

DWL-4-140 is a small molecule inhibitor of cyclized nucleotide-binding domain (CBD) of STING, selectively inhibits DNA-mediated IFNβ responses with IC50 of 617 nM.
DWL-4-140 interacts with the mmSTING CBD and inhibits the formation of STING multimeric complexes.
DWL-4-140 inhibits STING recruitment to TBK1.
DWL-4-140 suppresses the spontaneous expression of interferon-stimulated genes (ISGs) in Trex1−/− mice.
DWL-4-140 (5 mg/kg) effectively alleviates the lupus-like phenotype in Trex1-/- mice.

Physicochemical Properties

M.Wt 568.71
Formula C32H28N2O4S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

O=S(C1=CC=CC=C1)(N(C(C(C2=CC=CC=C2)=C=C(C#N)C3=CC=C(C)C=C3)CC)S(=O)(C4=CC=CC=C4)=O)=O

References

1. Hekang Du, et al. Biomed Pharmacother. 2023 Jul 20;165:115188.

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