DX-8951 derivative DXd | ADC payload, Topo I inhibitor

Chemical Structure : DX-8951 derivative DXd

CAS No.: 1599440-33-1

DX-8951 derivative DXd (DXd, Exatecan derivative for ADC)

Catalog No.: PC-28472Not For Human Use, Lab Use Only.

DX-8951 derivative DXd (DXd, Exatecan derivative for ADC) is a potent exatecan-derived topoisomerase I (Topo I) inhibitor (IC50=0.31 uM) and ADC payload.

Packing	Price	Stock
25 mg	$98	In stock
50 mg	$158	In stock
100 mg	$258	In stock
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Biological Activity

DX-8951 derivative DXd (DXd, Exatecan derivative for ADC) is a potent exatecan-derived topoisomerase I (Topo I) inhibitor (IC50=0.31 uM) and ADC payload.

Physicochemical Properties

M.Wt	493.49
Formula	C26H24FN3O6
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((1S,9S)-9-Ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl)-2-hydroxyacetamide

References

1. Ogitani Y, et al. Clin Cancer Res. 2016 Oct 15;22(20):5097-5108.

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DX-8951 derivative DXd (DXd, Exatecan derivative for ADC)

Biological Activity

Physicochemical Properties

References

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