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DXL-A-24

Chemical Structure : DXL-A-24

CAS No.: 2344686-24-2

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DXL-A-24

Catalog No.: PC-23411Not For Human Use, Lab Use Only.

DXL-A-24 is a spirocyclopiperazinium salt compound with antinociceptive effect, alleviates neuropathic pain by inhibiting CGRP expression, inhibits CaMKIIα phosphorylation.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

DXL-A-24 is a spirocyclopiperazinium salt compound with antinociceptive effect, alleviates neuropathic pain by inhibiting CGRP expression, inhibits CaMKIIα phosphorylation.
DXL-A-24 decreases the phosphorylation of CaMKIIα in the DRGs of CCI rats, inhibits the increase in CREB phosphorylation.
DXL-A-24 significantly inhibits nerve injury-induced hyperalgesia and the chemical-stimulated pain response in a dose-dependent manner.
DXL-A-24 is probably mediated by the activation of α7 nAChR and M4 mAChR.

Physicochemical Properties

M.Wt 365.24
Formula C15H20BrF3N2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

8-(4-(trifluoromethyl)phenyl)-5,8-diazaspiro[4.5]decan-5-ium bromide

References

1. Wang D, et al. Neurochem Res. 2019 Dec;44(12):2786-2795.

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