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Chemical Structure : DYC-1
Catalog No.: PC-22601Not For Human Use, Lab Use Only.
DYC-1 is a potent, dual-target DYRK2/HDAC8 inhibitor with IC50 of 5.27 and 8.06 nM respectively, exhibits potent antiproliferative and antitumor activity against liver cancer.
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DYC-1 is a potent, dual-target DYRK2/HDAC8 inhibitor with IC50 of 5.27 and 8.06 nM respectively, exhibits potent antiproliferative and antitumor activity against liver cancer.
DYC-1 exhibited superior antiproliferative activity against human liver cancer, especially SK-HEP-1 cells (IC50=0.17 uM), and had no significant inhibition on normal liver cells.
DYC-1 (5 -10 mg/kg) showed a strong inhibitory effect on the growth of SK-HEP-1 xenograft tumors with no significant side effects.
| M.Wt | 578.67 | |
| Formula | C28H31FN8O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zhang L, et al. Biomed Pharmacother. 2024 Jun 17;177:116839.
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