DYC-1 | DYRK2/HDAC8 inhibitor | Probechem Biochemicals

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Chemical Structure : DYC-1

DYC-1 (DYRK2/HDAC8 inhibitor)

Catalog No.: PC-22601Not For Human Use, Lab Use Only.

DYC-1 is a potent, dual-target DYRK2/HDAC8 inhibitor with IC50 of 5.27 and 8.06 nM respectively, exhibits potent antiproliferative and antitumor activity against liver cancer.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

DYC-1 is a potent, dual-target DYRK2/HDAC8 inhibitor with IC50 of 5.27 and 8.06 nM respectively, exhibits potent antiproliferative and antitumor activity against liver cancer.
DYC-1 exhibited superior antiproliferative activity against human liver cancer, especially SK-HEP-1 cells (IC50=0.17 uM), and had no significant inhibition on normal liver cells.
DYC-1 (5 -10 mg/kg) showed a strong inhibitory effect on the growth of SK-HEP-1 xenograft tumors with no significant side effects.

Physicochemical Properties

M.Wt	578.67
Formula	C28H31FN8O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	7-(4-(6-((4-(benzo[d]thiazol-5-yl)-5-fluoropyrimidin-2-yl)amino)nicotinoyl)piperazin-1-yl)-N-hydroxyheptanamide

References

1. Zhang L, et al. Biomed Pharmacother. 2024 Jun 17;177:116839.

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