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DYRK2 inhibitor C17

Chemical Structure : DYRK2 inhibitor C17

CAS No.: 2416195-65-6

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DYRK2 inhibitor C17

Catalog No.: PC-38492Not For Human Use, Lab Use Only.

DYRK2 inhibitor C17 is a potent, selective DYRK2 inhibitor with IC50 of 9 nM, weakly inhibits DYRK3 (IC50=68 nM), and does not inhibit DYRK1A/1B (IC50>2000 nM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    DYRK2 inhibitor C17 is a potent, selective DYRK2 inhibitor with IC50 of 9 nM, weakly inhibits DYRK3 (IC50=68 nM), and does not inhibit DYRK1A/1B (IC50>2000 nM).
    C17 showed outstanding selectivity for the human kinome containing 467 other human kinases.
    C17 showed synergistic 4E-BP1 phosphorylation suppression combined with AKT and MEK inhibitors.
    C17 impeded the store-operated calcium entry process (ORAI1 channel).

    Physicochemical Properties

    M.Wt 384.494
    Formula C21H24N2O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-(2,7-dimethoxy-9-((pyrrolidin-3-ylmethyl)thio)acridin-4-yl)methanol

    References

    1. Tiantian Wei, et al. Elife. 2022 Apr 19;11:e77696.

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