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Chemical Structure : DYRK2 inhibitor C17
Catalog No.: PC-38492Not For Human Use, Lab Use Only.
DYRK2 inhibitor C17 is a potent, selective DYRK2 inhibitor with IC50 of 9 nM, weakly inhibits DYRK3 (IC50=68 nM), and does not inhibit DYRK1A/1B (IC50>2000 nM).
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DYRK2 inhibitor C17 is a potent, selective DYRK2 inhibitor with IC50 of 9 nM, weakly inhibits DYRK3 (IC50=68 nM), and does not inhibit DYRK1A/1B (IC50>2000 nM).
C17 showed outstanding selectivity for the human kinome containing 467 other human kinases.
C17 showed synergistic 4E-BP1 phosphorylation suppression combined with AKT and MEK inhibitors.
C17 impeded the store-operated calcium entry process (ORAI1 channel).
| M.Wt | 384.494 | |
| Formula | C21H24N2O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Tiantian Wei, et al. Elife. 2022 Apr 19;11:e77696.
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