Chemical Structure : DYT-40
CAS No.:
1569312-97-5
DYT-40
(DYT40)
Catalog No.: PC-27553Not For Human Use, Lab Use Only.
DYT-40 is a small molecule inhibitor of Astrocyte elevated gene-1 (AEG-1) expression and NF-κB nuclear translocation, blocks malignant glioblastoma growth and invasion by inhibiting AEG-1 and NF-κB signaling pathways.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
DYT-40 is a small molecule inhibitor of Astrocyte elevated gene-1 (AEG-1) expression and NF-κB nuclear translocation, blocks malignant glioblastoma growth and invasion by inhibiting AEG-1 and NF-κB signaling pathways.
DYT-40 inhibited the proliferation of malignant glioblastoma cells.
DYT-40 induced apoptosis in U251 and U87 cells. DYT-40 inhibited epithelial-mesenchymal transition and invasion of U251 and U87 cells.
DYT-40 suppressed AEG-1/NF-κB, PI3K/AKT and MAPK pathways, decreased the phosphorylation of AKT, and ERK kinase.
DYT-40 (5, 10 and 20 mg/kg) reduced tumor volume and induced apoptotic cell death in the rat glioma model.
Physicochemical Properties
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M.Wt
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455.85
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Formula
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C22H18ClN3O6
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(E)-2-(2-(4-chlorostyryl)-5-nitro-1H-imidazol-1-yl)ethyl 2,3-dihydrobenzo[b][1,4]dioxine-6-carboxylate
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References
1. Zou M, et al. Sci Rep. 2016 Jun 2;6:27331.
2. Yong-Tao Duan, et al. Bioorg Med Chem. 2014 Jun 1;22(11):2947-54.
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