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DZ-2384

Chemical Structure : DZ-2384

CAS No.: 1403850-91-8

DZ-2384 (DZ2384)

Catalog No.: PC-35304Not For Human Use, Lab Use Only.

DZ-2384 (DZ2384) is a microtubule-targeting agent, exhibits potent antitumor activity in models of multiple cancer types.

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    Biological Activity

    DZ-2384 (DZ2384) is a microtubule-targeting agent, exhibits potent antitumor activity in models of multiple cancer types.
    DZ-2384 binds the vinca domain of tubulin, DZ-2384 has potent antitumor activity as a single agent and in combination with gemcitabine both in vitro and in vivo, enhances gemcitabine activity in mouse models of pancreatic cancer.

    Physicochemical Properties

    M.Wt 645.677
    Formula C34H36FN5O7
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (S)-N-((15aR,110bS,3S,6S)-3-(tert-butyl)-19-fluoro-24-(4-(hydroxymethyl)oxazol-2-yl)-5-oxo-15a,110b-dihydro-16H-4-aza-1(10b,2)-benzofuro[2,3-b]indola-2(5,2)-oxazolacycloheptaphane-6-yl)-2-hydroxy-3-methylbutanamide

    References

    1. Ding H, et al. Angew Chem Int Ed Engl. 2015 Apr 13;54(16):4818-22.

    2. Wieczorek M, et al. Sci Transl Med. 2016 Nov 16;8(365):365ra159.

    3. Bernier C, et al. Anticancer Drugs. 2018 Jun 22. doi: 10.1097/CAD.0000000000000653.

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