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Dabigatran etexilate

Chemical Structure : Dabigatran etexilate

CAS No.: 211915-06-9

Dabigatran etexilate (BIBR-1048, BIBR1048)

Catalog No.: PC-42506Not For Human Use, Lab Use Only.

Dabigatran etexilate (BIBR1048) is a prodrug of BIBR-953, which is a potent nonpeptide thrombin inhibitor with Ki of 4.5 nM.

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Biological Activity

Dabigatran etexilate (BIBR1048) is a prodrug of BIBR-953, which is a potent nonpeptide thrombin inhibitor with Ki of 4.5 nM.
BIBR1048 is 10-fold less potent for Trypsin and no activity against Factor Xa, Plasmin, tPA and activated protein C.
BIBR1048 exhibits strong and long-lasting anticoagulant effects ex vivo and strong oral activity in different animal species.

Physicochemical Properties

M.Wt 627.7332
Formula C34H41N7O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

b-Alanine, N-[[2-[[[4-[[[(hexyloxy)carbonyl]amino]iminomethyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-, ethyl ester

References

1. Hauel NH, et al. J Med Chem. 2002 Apr 25;45(9):1757-66.

2. Wienen W, et al. Thromb Haemost. 2007 Jul;98(1):155-62.

3. Baetz BE, et al. Pharmacotherapy. 2008 Nov;28(11):1354-73.

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