Chemical Structure : Dabigatran etexilate mesylate
CAS No.:
872728-81-9
Dabigatran etexilate mesylate
(BIBR 1048MS;Dabigatran etexilate methanesulfonate)
Catalog No. : PC-42507Not For Human Use, Lab Use Only.
A prodrug of BIBR-953, which is a potent nonpeptide thrombin inhibitor with Ki of 4.5 nM.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-4250701
Biological Activity
A prodrug of BIBR-953, which is a potent nonpeptide thrombin inhibitor with Ki of 4.5 nM; 10-fold less potent for Trypsin and no activity against Factor Xa, Plasmin, tPA and activated protein C; exhibits strong and long-lasting anticoagulant effects ex vivo and strong oral activity in different animal species.
Thrombosis
Approved
Physicochemical Properties
M.Wt
723.8389
Formula
C35H45N7O8S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
β-Alanine, N-[[2-[[[4-[[[(hexyloxy)carbonyl]amino]iminomethyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-, ethyl ester, methanesulfonate (1:1)
References
1. Hauel NH, et al. J Med Chem. 2002 Apr 25;45(9):1757-66.
2. Wienen W, et al. Thromb Haemost. 2007 Jul;98(1):155-62.
3. Baetz BE, et al. Pharmacotherapy. 2008 Nov;28(11):1354-73.
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