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Daclatasvir

Chemical Structure : Daclatasvir

CAS No.: 1009119-64-5

Daclatasvir (BMS-790052;EBP 883;BMS 790052)

Catalog No.: PC-42604Not For Human Use, Lab Use Only.

Daclatasvir (BMS-790052) is a potent HCV NS5A inhibitor with EC50 of <50 pM against genotype 1 replicons.

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50 mg $128 In stock
100 mg $198 In stock
200 mg $288 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Daclatasvir (BMS-790052) is a potent HCV NS5A inhibitor with EC50 of <50 pM against genotype 1 replicons.
Daclatasvir (BMS-790052) exhibits picomolar EC(50) towards replicons expressing a broad range of HCV genotypes and the JFH-1 genotype 2a infectious virus in cell culture.

Physicochemical Properties

M.Wt 738.875
Formula C40H50N8O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 40 mg/mL

Chemical Name/SMILES

Carbamic acid, N,N'-[[1,1'-biphenyl]-4,4'-diylbis[1H-imidazole-5,2-diyl-(2S)-2,1-pyrrolidinediyl[(1S)-1-(1-methylethyl)-2-oxo-2,1-ethanediyl]]]bis-, C,C'-dimethyl ester

References

1. Gao M, et al. Nature. 2010 May 6;465(7294):96-100.

2. Lemm JA, et al. Antimicrob Agents Chemother. 2011 Aug;55(8):3795-802.

3. Fridell RA, et al. Antimicrob Agents Chemother. 2010 Sep;54(9):3641-50.

4. Fridell RA, et al. J Virol. 2011 Jul;85(14):7312-20.

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