Dalcetrapib (JTT-705, RO4607381)

Chemical Structure : Dalcetrapib

CAS No.: 211513-37-0

Catalog No.: PC-21183Not For Human Use, Lab Use Only.

Dalcetrapib (JTT-705, RO4607381) is an orally active cholesteryl ester transfer protein (CETP) inhibitor with IC50 of 204.6 nM and 6 μM against recombinant human (rh) CETP and human plasma CETP, respectively.

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10 mg	$98	In stock
25 mg	$158	In stock
50 mg	$248	In stock
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Biological Activity

Dalcetrapib (JTT-705, RO4607381) is an orally active cholesteryl ester transfer protein (CETP) inhibitor with IC50 of 204.6 nM and 6 μM against recombinant human (rh) CETP and human plasma CETP, respectively.
Dalcetrapib (JTT-705, RO4607381) dose-dependently increases pre-β-HDL formation.
Dalcetrapib (JTT-705, RO4607381) inhibits the CETP activity of media in HepG2 in a dose-dependent manner.
Dalcetrapib (JTT-705, RO4607381) significantly increases fecal elimination of neutral sterols, bile acids, and plasma HDL-cholesterol in vivo.

Physicochemical Properties

M.Wt	389.60
Formula	C23H35NO2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	S-(2-(1-(2-Ethylbutyl)cyclohexane-1-carboxamido)phenyl) 2-methylpropanethioate

References

1. Niesor EJ, et al. J Lipid Res. 2010, 51(12), 3443-3454.

2. Shinkai H, et al. J Med Chem. 2000, 43(19), 3566-3572.