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Chemical Structure : Dalcetrapib
CAS No.: 211513-37-0
Catalog No.: PC-21183Not For Human Use, Lab Use Only.
Dalcetrapib (JTT-705, RO4607381) is an orally active cholesteryl ester transfer protein (CETP) inhibitor with IC50 of 204.6 nM and 6 μM against recombinant human (rh) CETP and human plasma CETP, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | $488 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Dalcetrapib (JTT-705, RO4607381) is an orally active cholesteryl ester transfer protein (CETP) inhibitor with IC50 of 204.6 nM and 6 μM against recombinant human (rh) CETP and human plasma CETP, respectively.
Dalcetrapib (JTT-705, RO4607381) dose-dependently increases pre-β-HDL formation.
Dalcetrapib (JTT-705, RO4607381) inhibits the CETP activity of media in HepG2 in a dose-dependent manner.
Dalcetrapib (JTT-705, RO4607381) significantly increases fecal elimination of neutral sterols, bile acids, and plasma HDL-cholesterol in vivo.
| M.Wt | 389.60 | |
| Formula | C23H35NO2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
S-(2-(1-(2-Ethylbutyl)cyclohexane-1-carboxamido)phenyl) 2-methylpropanethioate |
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1. Niesor EJ, et al. J Lipid Res. 2010, 51(12), 3443-3454.
2. Shinkai H, et al. J Med Chem. 2000, 43(19), 3566-3572.
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