Catalog No.: PC-49132Not For Human Use, Lab Use Only.
Dalmelitinib is a potent, selective c-Met tyrosine kinase inhibitor with IC50 of 0.7 nM, inhibits cell growth of gastric cells SNU5 with IC50 of 2.0 nM, binds to the ATP-binding region of c-MET kinase.
Dalmelitinib is a potent, selective c-Met tyrosine kinase inhibitor with IC50 of 0.7 nM, inhibits cell growth of gastric cells SNU5 with IC50 of 2.0 nM, binds to the ATP-binding region of c-MET kinase.
Dalmelitinib has a better inhibiting activity than SGX-523 in a dosedependent manner against different human tumor cell lines comprising human gastric (MKN-45) and human non-small cell lung (NCI-H1993).
Dalmelitinib (10, 30, 60 mg/kg) significantly inhibited the tumor (MKN-45) growth in nude mice and the inhibitory rates were 29.5%, 34.2%, and 61.4%, respectively.
