Dalosirvat (SM04554)

Chemical Structure : Dalosirvat

CAS No.: 1360540-81-3

Catalog No.: PC-38354Not For Human Use, Lab Use Only.

Dalosirvat (SM04554) is a small-molecule Wnt pathway modulator, activates Wnt with IC50 of 28-29 nM, with potential topical treatment for androgenetic alopecia.

Packing	Price	Stock
10 mg	$128	In stock
25 mg	$218	In stock
50 mg	$358	In stock
100 mg		Get quote

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Biological Activity

Dalosirvat (SM04554) is a small-molecule Wnt pathway modulator, activates Wnt with IC50 of 28-29 nM, with potential topical treatment for androgenetic alopecia.
SM04554 increased total and nuclear β-catenin, versican and Ki-67 specifically in hair follicles.
SM04554 increased follicle numbers and hair growth.

Physicochemical Properties

M.Wt	296.322
Formula	C18H16O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-4-phenylbutane-1,4-dione

References

1. V. Deshmukh, et al. DOI: https://doi.org/10.1016/j.jid.2017.02.735

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