Danoprevir | HCV NS3/4A inhibitor | Probechem Biochemicals

Chemical Structure : Danoprevir

CAS No.: 850876-88-9

Danoprevir (ITMN-191, R-7227, RO-5190591, RG7227)

Catalog No.: PC-42478Not For Human Use, Lab Use Only.

Danoprevir (ITMN-191, R-7227) is a potent, highly selective, orally available, peptidomimetic HCV NS3/4A protease inhibitor with IC50 of 0.2-0.4 nM (GT1a, 1b, 4, 5 and 6), 1.6 nM (GT2b).

Packing	Price	Stock
5 mg	$98	In stock
10 mg	$148	In stock
25 mg	$258	In stock
50 mg	$398	In stock
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Biological Activity

Danoprevir (ITMN-191, R-7227) is a potent, highly selective, orally available, peptidomimetic HCV NS3/4A protease inhibitor with IC50 of 0.2-0.4 nM (GT1a, 1b, 4, 5 and 6), 1.6 nM (GT2b).
Danoprevir shows favorable potency profile against multiple HCV genotypes 1–6 and key mutants (replicon GT1b, EC50=1.6 nM).

Physicochemical Properties

M.Wt	731.8312
Formula	C35H46FN5O9S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2H-Isoindole-2-carboxylic acid, 4-fluoro-1,3-dihydro-, (2R,6S,13aS,14aR,16aS)-14a-[[(cyclopropylsulfonyl)amino]carbonyl]-6-[[(1,1-dimethylethoxy)carbonyl]amino]-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-5,16-dioxocyclopropa[e]pyrrolo[1,2-a]

References

1. Bae A, et al. Antimicrob Agents Chemother. 2010 Dec;54(12):5288-97.

2. Moucari R, et al. Gut. 2010 Dec;59(12):1694-8.

3. Jiang Y, et al. J Med Chem. 2014 Mar 13;57(5):1753-69.

4. Schaefer CJ, et al. Antimicrob Agents Chemother. 2011 Jul;55(7):3125-32.

Danoprevir (ITMN-191, R-7227, RO-5190591, RG7227)

Biological Activity

Physicochemical Properties

References

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