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Chemical Structure : Dapagliflozin
CAS No.: 461432-26-8
Catalog No.: PC-42592Not For Human Use, Lab Use Only.
Dapagliflozin (BMS-512148) is a potent, selective, orally active hSGLT2 inhibitor with EC50 of 1.12 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $118 | In stock | |
| 100 mg | $188 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Dapagliflozin (BMS-512148) is a potent, selective, orally active hSGLT2 inhibitor with EC50 of 1.12 nM.
Dapagliflozin (BMS-512148) displays >300-fold selectivity over hSGLT1 (EC50=330 nM), highly selectivity versus GLUT transporters.
Dapagliflozin (BMS-512148) also is a potent selective inhibitor of rSGLT2 (EC50=3 nM), with 200-fold selectivity versus rSGLT1.
Dapagliflozin (BMS-512148) significantly improves glucose homeostasis, reduces blood glucose levels in hyperglycemic streptozotocin (STZ) rats.
| M.Wt | 408.8726 | |
| Formula | C21H25ClO6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
D-Glucitol, 1,5-anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-, (1S)- |
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1. Meng W, et al. J Med Chem. 2008 Mar 13;51(5):1145-9.
2. Han S, et al. Diabetes. 2008 Jun;57(6):1723-9.
3. Wilson C. Nat Rev Endocrinol. 2010 Oct;6(10):531.
4. Komoroski B, et al. Clin Pharmacol Ther. 2009 May;85(5):513-9.
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