Daptomycin | Antibiotic | Probechem Biochemicals

Chemical Structure : Daptomycin

CAS No.: 103060-53-3

Daptomycin (LY 146032, LY-146032)

Catalog No.: PC-25829Not For Human Use, Lab Use Only.

Daptomycin is (LY 146032) is a cyclic lipopeptide antibiotic against gram-positive organisms, binds to the bacterial cell membranes, causing rapid depolarization of the membrane due to potassium efflux and associated disruption of DNA, RNA, and protein synthesis, induces rapid concentration-dependent bacterial death.

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Biological Activity

Physicochemical Properties

M.Wt	1620.69
Formula	C72H101N17O26
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,2'-((3S,6S,9R,15S,18R,21S,24S,30S,31R)-30-((S)-2-((R)-4-Amino-2-((S)-2-decanamido-3-(1H-indol-3-yl)propanamido)-4-oxobutanamido)-3-carboxypropanamido)-3-(2-(2-aminophenyl)-2-oxoethyl)-24-(3-aminopropyl)-6-((R)-1-carboxypropan-2-yl)-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-oxa-4,7,10,13,16,19,22,25,28-nonaazacyclohentriacontane-15,21-diyl)diacetic acid

References

1. Eliopoulos GM, et al. Antimicrob Agents Chemother. 1986 Oct;30(4):532-5.

2. Verbist L. In vitro activity of LY146032, a new lipopeptide antibiotic, against gram-positive cocci. Antimicrob Agents Chemother. 1987 Feb;31(2):340-2.

Daptomycin (LY 146032, LY-146032)

Biological Activity

Physicochemical Properties

References

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