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Chemical Structure : Darapladib
CAS No.: 356057-34-6
Catalog No.: PC-42634Not For Human Use, Lab Use Only.
Darapladib (SB480848) is a potent Lp-PLA2 inhibitor with IC50 of 0.25 nM, shows an enhanced in vitro and in vivo profile versus SB-435495.
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|---|---|---|---|
| 1 mg (Free Sample) | $18 | In stock | |
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $348 | In stock | |
| 50 mg | $548 | In stock | |
| 100 mg | Get quote |
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Darapladib (SB480848) is a potent Lp-PLA2 inhibitor with IC50 of 0.25 nM, shows an enhanced in vitro and in vivo profile versus SB-435495.
| M.Wt | 666.7711 | |
| Formula | C36H38F4N4O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1H-Cyclopentapyrimidine-1-acetamide, N-[2-(diethylamino)ethyl]-2-[[(4-fluorophenyl)methyl]thio]-4,5,6,7-tetrahydro-4-oxo-N-[[4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]methyl]- |
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1. Blackie JA, et al. Bioorg Med Chem Lett. 2003 Mar 24;13(6):1067-70.
2. Wilensky RL, et al. Nat Med. 2008 Oct;14(10):1059-66.
3. Serruys PW, et al. Circulation. 2008 Sep 9;118(11):1172-82.
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