Chemical Structure : Darapladib
CAS No.:
356057-34-6
Darapladib
(SB-480848, SB480848)
Catalog No.: PC-42634Not For Human Use, Lab Use Only.
Darapladib (SB-480848) is a potent Lp-PLA2 inhibitor with IC50 of 0.25 nM, shows an enhanced in vitro and in vivo profile versus SB-435495.
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Purity & Documentation Purity:
>98% (HPLC)
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Biological Activity
Darapladib (SB-480848) is a potent Lp-PLA2 inhibitor with IC50 of 0.25 nM, shows an enhanced in vitro and in vivo profile versus SB-435495.
Physicochemical Properties
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M.Wt
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666.7711
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Formula
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C36H38F4N4O2S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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1H-Cyclopentapyrimidine-1-acetamide, N-[2-(diethylamino)ethyl]-2-[[(4-fluorophenyl)methyl]thio]-4,5,6,7-tetrahydro-4-oxo-N-[[4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]methyl]-
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References
1. Blackie JA, et al. Bioorg Med Chem Lett. 2003 Mar 24;13(6):1067-70.
2. Wilensky RL, et al. Nat Med. 2008 Oct;14(10):1059-66.
3. Serruys PW, et al. Circulation. 2008 Sep 9;118(11):1172-82.
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