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Darexaban

Chemical Structure : Darexaban

CAS No.: 365462-23-3

Darexaban (YM150, YM-150)

Catalog No.: PC-60995Not For Human Use, Lab Use Only.

Darexaban (YM150) is potent, selective and orally available factor Xa (FXa) inhibitor with IC50 of 54.6 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Darexaban (YM150) is potent, selective and orally available factor Xa (FXa) inhibitor with IC50 of 54.6 nM.
Darexaban (YM150) displays high selectivities over other related serine proteases, such as trypsin, thrombin and kallikrein (IC50>10 uM).
Darexaban (YM150) demonstrates potent anticoagulant activities both in vitro and in vivo, shows potential for prevention and treatment of thromboembolic diseases.

Physicochemical Properties

M.Wt 474.561
Formula C27H30N4O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-[2-hydroxy-6-(4-methoxybenzamido)phenyl]-4- (4-methyl-1,4-diazepan-1-yl)benzamide

References

1. Hirayama F, et al. J Med Chem. 2011 Dec 8;54(23):8051-65.

2. Iwatsuki Y, et al. Eur J Pharmacol. 2011 Dec 30;673(1-3):49-55.

3. Funatsu T, et al. J Thromb Haemost. 2012 Apr;10(4):703-5.

4. Steg PG, et al. Eur Heart J. 2011 Oct;32(20):2541-54.

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