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Darexaban

Chemical Structure : Darexaban

CAS No.: 365462-23-3

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Darexaban (YM150;YM-150;YM 150)

Catalog No.: PC-60995Not For Human Use, Lab Use Only.

A potent, selective and orally available factor Xa (FXa) inhibitor with IC50 of 54.6 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A potent, selective and orally available factor Xa (FXa) inhibitor with IC50 of 54.6 nM; displays high selectivities over other related serine proteases, such as trypsin, thrombin and kallikrein (IC50>10 uM); demonstrates potent anticoagulant activities both in vitro and in vivo, shows potential for prevention and treatment of thromboembolic diseases.

Thrombosis

Phase 2 Discontinued

Physicochemical Properties

M.Wt 474.561
Formula C27H30N4O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-[2-hydroxy-6-(4-methoxybenzamido)phenyl]-4- (4-methyl-1,4-diazepan-1-yl)benzamide

References

1. Hirayama F, et al. J Med Chem. 2011 Dec 8;54(23):8051-65.

2. Iwatsuki Y, Eur J Pharmacol. 2011 Dec 30;673(1-3):49-55.

3. Funatsu T, et al. J Thromb Haemost. 2012 Apr;10(4):703-5.

4. Steg PG, et al. Eur Heart J. 2011 Oct;32(20):2541-54.

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