Chemical Structure : Darexaban
CAS No.: 365462-23-3
Catalog No.: PC-60995Not For Human Use, Lab Use Only.
Darexaban (YM150) is potent, selective and orally available factor Xa (FXa) inhibitor with IC50 of 54.6 nM.
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Darexaban (YM150) is potent, selective and orally available factor Xa (FXa) inhibitor with IC50 of 54.6 nM.
Darexaban (YM150) displays high selectivities over other related serine proteases, such as trypsin, thrombin and kallikrein (IC50>10 uM).
Darexaban (YM150) demonstrates potent anticoagulant activities both in vitro and in vivo, shows potential for prevention and treatment of thromboembolic diseases.
M.Wt | 474.561 | |
Formula | C27H30N4O4 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
N-[2-hydroxy-6-(4-methoxybenzamido)phenyl]-4- (4-methyl-1,4-diazepan-1-yl)benzamide |
1. Hirayama F, et al. J Med Chem. 2011 Dec 8;54(23):8051-65.
2. Iwatsuki Y, et al. Eur J Pharmacol. 2011 Dec 30;673(1-3):49-55.
3. Funatsu T, et al. J Thromb Haemost. 2012 Apr;10(4):703-5.
4. Steg PG, et al. Eur Heart J. 2011 Oct;32(20):2541-54.
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