Darusentan | ETA receptor antagonist | Probechem Biochemicals

Chemical Structure : Darusentan

CAS No.: 171714-84-4

Darusentan (Lu-135252, Lu 135252)

Catalog No.: PC-25045Not For Human Use, Lab Use Only.

Darusentan (Lu-135252) is a selective endothelin receptor A (ETA) receptor antagonist with binding Ki of 1.4 nM, >100-fold selective over ET-B receptor.

Packing	Price	Stock
5 mg	$78	In stock
10 mg	$118	In stock
25 mg	$198	In stock
50 mg	$348	In stock
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Biological Activity

Darusentan (Lu-135252) is a selective endothelin receptor A (ETA) receptor antagonist with binding Ki of 1.4 nM, >100-fold selective over ET-B receptor.

Physicochemical Properties

M.Wt	410.43
Formula	C22H22N2O6
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-((4,6-Dimethoxypyrimidin-2-yl)oxy)-3-methoxy-3,3-diphenylpropanoic acid

References

1. Frank Enseleit, et al. Ther Adv Cardiovasc Dis. 2010 Aug;4(4):231-40.

2. Liang F, et al. Can J Physiol Pharmacol. 2010 Aug;88(8):840-9.

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Darusentan (Lu-135252, Lu 135252)

Biological Activity

Physicochemical Properties

References

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