Chemical Structure : Dasotraline hydrochloride
CAS No.:
675126-08-6
Dasotraline hydrochloride
(SEP 225289 hydrochloride;SEP-225289 hydrochloride;SEP225289 hydrochloride)
Catalog No.: PC-43257Not For Human Use, Lab Use Only.
Dasotraline (SEP-225289) is a novel triple reuptake inhibitor, antidepressant agent that blocks norepinephrine (NE), dopamine (DA) and serotonin (5-HT) transporters with IC50 values of 4, 6, and 11 nM, respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Dasotraline (SEP-225289) is a novel triple reuptake inhibitor, antidepressant agent that blocks norepinephrine (NE), dopamine (DA) and serotonin (5-HT) transporters with IC50 values of 4, 6, and 11 nM, respectively; demonstrates potential for the treatment of attention-deficit/hyperactivity disorder (ADHD).
Physicochemical Properties
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M.Wt
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328.6639
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Formula
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C16H16Cl3N
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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DMSO: ≥ 31 mg/mL
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Chemical Name/SMILES
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1-Naphthalenamine, 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-, hydrochloride (1:1), (1R,4S)-
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References
1. Koblan KS, et al. Neuropsychopharmacology. 2015 Nov;40(12):2745-52.
2. Hopkins SC, et al. Clin Drug Investig. 2016 Feb;36(2):137-46.
3. Guiard BP, et al. Int J Neuropsychopharmacol. 2011 Mar;14(2):211-23.
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