Daun02 | Topoisomerase inhibitor | Probechem Biochemicals

Chemical Structure : Daun02

CAS No.: 290304-24-4

Daun02 (Daun 02, Daun-02)

Catalog No.: PC-43365Not For Human Use, Lab Use Only.

Daun02 is a prodrug that is converted by β-galactosidase to Daunorubicin and topoisomerase inhibitor, specifically attenuates cocaine-induced locomotor activity , also attenuates cocaine-induced β-galactosidase expression.

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Biological Activity

Daun02 is a prodrug that is converted by β-galactosidase to Daunorubicin and topoisomerase inhibitor, specifically attenuates cocaine-induced locomotor activity , also attenuates cocaine-induced β-galactosidase expression.
Daunorubicin, the active product of Daun02 metabolism by β-galactosidase, decreases the activity of MSNs in rat brain slices and that Daun02 strongly decreases the excitability of rat MSN primary cultures expressing β-galactosidase upon D1 dopamine receptor stimulation.
Daun02 selectively inactivate only those neurons activated by cocaine in an environment repeatedly paired with drug injections.

Physicochemical Properties

M.Wt	884.7895
Formula	C41H44N2O20
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1R,2R,6S,18R,20S)-3-nitro-4-((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-tetrahydro-2H-pyran-2-yloxy)benzyl (2S,3S,4S,6R)-6-(3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yloxy)-3-hydroxy-2-methyl-tetrahydro-2H

References

1. Koya E, et al. Nat Neurosci. 2009 Aug;12(8):1069-73.

2. Farquhar D, et al. Cancer Chemother Pharmacol. 2002 Jul;50(1):65-70.

3. Koya E, et al. Curr Protoc Neurosci. 2016 Jul 1;76:8.36.1-8.36.17.

4. Cruz FC, et al. J Neurosci. 2014 May 28;34(22):7437-46.

Daun02 (Daun 02, Daun-02)

Biological Activity

Physicochemical Properties

References

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