Chemical Structure : Daun02
CAS No.: 290304-24-4
Catalog No.: PC-43365Not For Human Use, Lab Use Only.
Daun02 is a prodrug that is converted by β-galactosidase to Daunorubicin and topoisomerase inhibitor, specifically attenuates cocaine-induced locomotor activity , also attenuates cocaine-induced β-galactosidase expression.
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Daun02 is a prodrug that is converted by β-galactosidase to Daunorubicin and topoisomerase inhibitor, specifically attenuates cocaine-induced locomotor activity , also attenuates cocaine-induced β-galactosidase expression.
Daunorubicin, the active product of Daun02 metabolism by β-galactosidase, decreases the activity of MSNs in rat brain slices and that Daun02 strongly decreases the excitability of rat MSN primary cultures expressing β-galactosidase upon D1 dopamine receptor stimulation.
Daun02 selectively inactivate only those neurons activated by cocaine in an environment repeatedly paired with drug injections.
M.Wt | 884.7895 | |
Formula | C41H44N2O20 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
(1R,2R,6S,18R,20S)-3-nitro-4-((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-tetrahydro-2H-pyran-2-yloxy)benzyl (2S,3S,4S,6R)-6-(3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yloxy)-3-hydroxy-2-methyl-tetrahydro-2H |
1. Koya E, et al. Nat Neurosci. 2009 Aug;12(8):1069-73.
2. Farquhar D, et al. Cancer Chemother Pharmacol. 2002 Jul;50(1):65-70.
3. Koya E, et al. Curr Protoc Neurosci. 2016 Jul 1;76:8.36.1-8.36.17.
4. Cruz FC, et al. J Neurosci. 2014 May 28;34(22):7437-46.
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