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Daunorubicin

Chemical Structure : Daunorubicin

CAS No.: 20830-81-3

Daunorubicin (RP13057;Daunomycin;Rubidomycin)

Catalog No.: PC-43367Not For Human Use, Lab Use Only.

Daunorubicin is potent topoisomerase II (Topo II) inhibitor, interacts with DNA by intercalation and inhibition of macromolecular biosynthesis in cancer cells.

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Biological Activity

Daunorubicin is potent topoisomerase II (Topo II) inhibitor, interacts with DNA by intercalation and inhibition of macromolecular biosynthesis in cancer cells; Daunorubicin is a chemotherapy agent used to treat multiple cancer, secifically used for acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL), chronic myelogenous leukemia (CML), and Kaposi's sarcoma; Daunorubicin and it's derivatives are widely used as payloads in antibody-drug conjugates (ADCs).

Chemotherapeutic Agents

Approved

Physicochemical Properties

M.Wt 527.5198
Formula C27H29NO10
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, (8S,10S)-

References

1. Latif ZA, et al. Cancer. 1980 Mar 15;45(6):1326-33.

2. Hurwitz E, et al. Int J Cancer. 1979 Oct 15;24(4):461-70.

3. Aboud-Pirak E, et al. Proc Natl Acad Sci U S A. 1989 May;86(10):3778-81.

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