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Daunorubicin hydrochloride

Chemical Structure : Daunorubicin hydrochloride

CAS No.: 23541-50-6

Daunorubicin hydrochloride (RP 13057 Hydrochloride;Daunomycin;RP13057 Hydrochloride;RP-13057 Hydrochloride;Rubidomycin hydrochloride)

Catalog No.: PC-43366Not For Human Use, Lab Use Only.

Daunorubicin (RP13057) hydrochloride is potent topoisomerase II (Topo II) inhibitor, interacts with DNA by intercalation and inhibition of macromolecular biosynthesis in cancer cells.

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25 mg $88 In stock
50 mg $138 In stock
100 mg $218 In stock
250 mg $358 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Daunorubicin (RP13057) hydrochloride is potent topoisomerase II (Topo II) inhibitor, interacts with DNA by intercalation and inhibition of macromolecular biosynthesis in cancer cells.
Daunorubicin is a chemotherapy agent used to treat multiple cancer, secifically used for acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL), chronic myelogenous leukemia (CML), and Kaposi's sarcoma.
Daunorubicin and it's derivatives are widely used as payloads in antibody-drug conjugates (ADCs).

Physicochemical Properties

M.Wt 563.9808
Formula C27H30ClNO10
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

H2O: ≥ 34 mg/mL

Chemical Name/SMILES

5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, hydrochloride (1:1), (8S,10S)-

References

1. Latif ZA, et al. Cancer. 1980 Mar 15;45(6):1326-33.

2. Hurwitz E, et al. Int J Cancer. 1979 Oct 15;24(4):461-70.

3. Aboud-Pirak E, et al. Proc Natl Acad Sci U S A. 1989 May;86(10):3778-81.

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