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Chemical Structure : Daunorubicin hydrochloride
CAS No.: 23541-50-6
Catalog No.: PC-43366Not For Human Use, Lab Use Only.
Daunorubicin (RP13057) hydrochloride is potent topoisomerase II (Topo II) inhibitor, interacts with DNA by intercalation and inhibition of macromolecular biosynthesis in cancer cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $88 | In stock | |
| 50 mg | $138 | In stock | |
| 100 mg | $218 | In stock | |
| 250 mg | $358 | In stock | |
| 1 g | Get quote |
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Daunorubicin (RP13057) hydrochloride is potent topoisomerase II (Topo II) inhibitor, interacts with DNA by intercalation and inhibition of macromolecular biosynthesis in cancer cells.
Daunorubicin is a chemotherapy agent used to treat multiple cancer, secifically used for acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL), chronic myelogenous leukemia (CML), and Kaposi's sarcoma.
Daunorubicin and it's derivatives are widely used as payloads in antibody-drug conjugates (ADCs).
| M.Wt | 563.9808 | |
| Formula | C27H30ClNO10 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
H2O: ≥ 34 mg/mL |
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| Chemical Name/SMILES |
5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, hydrochloride (1:1), (8S,10S)- |
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1. Latif ZA, et al. Cancer. 1980 Mar 15;45(6):1326-33.
2. Hurwitz E, et al. Int J Cancer. 1979 Oct 15;24(4):461-70.
3. Aboud-Pirak E, et al. Proc Natl Acad Sci U S A. 1989 May;86(10):3778-81.
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