Chemical Structure : DdBIC
CAS No.:
3085711-53-8
DdBIC
Catalog No.: PC-26968Not For Human Use, Lab Use Only.
DdBIC is a specific small molecule agonist of orphan nuclear receptor Nur77, binds to ligand binding domain (LBD) with ITC Kd of 714 nM, triggers GSDMC-mediated pyroptosis by regulating heme levels.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
DdBIC is a specific small molecule agonist of orphan nuclear receptor Nur77, binds to ligand binding domain (LBD) with ITC Kd of 714 nM, triggers GSDMC-mediated pyroptosis by regulating heme levels.
DdBIC activates the PERK-mediated ISR pathway to induce pyroptosis.
DdBIC promotes the accumulation of granzyme B (GZMB) in the cytosol.
DdBIC induces Nur77 translocation to the mitochondria to activate the hemoprotein SDHA to overconsume succinyl-CoA, subsequently disrupting the homeostasis of heme in the SDH complex and resulting in electron leakage to induce mito-ROS production.
DdBIC induces downstream OPA1 cleavage and subsequent released into the cytoplasm.
Cytosolic OPA1 activated PERK to induce the integrated stress response (ISR), which further activated granzyme B to cleave GSDMC, culminating in the induction of pyroptosis.
Physicochemical Properties
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M.Wt
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330.47
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Formula
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C20H30N2O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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dodecyl 1H-benzo[d]imidazole-6-carboxylate
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References
1. Liu-Zheng Wu, et al. Signal Transduct Target Ther. 2025 Dec 17;10(1):413.
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