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Chemical Structure : Debio 0617B
Catalog No.: PC-60417Not For Human Use, Lab Use Only.
Debio 0617B is a first-in-class, multi-kinase inhibitor that targets pSTAT3 and/or pSTAT5 in cancer cells through combined inhibition of JAK, SRC, ABL, and class III/V RTKs (Kd<100 nM).
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Debio 0617B is a first-in-class, multi-kinase inhibitor that targets pSTAT3 and/or pSTAT5 in cancer cells through combined inhibition of JAK, SRC, ABL, and class III/V RTKs (Kd<100 nM).
Debio 0617B showes dose-dependent inhibition of pSTAT3 in STAT3-activated carcinoma cell lines (IC50=175 nM).
Debio 0617B also showes potent antiproliferative activity in a panel of cancer cell lines and in patient-derived tumor xenografts.
| M.Wt | 581.98 | |
| Formula | C28H23ClF3N7O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Murone M, et al. Mol Cancer Ther. 2016 Oct;15(10):2334-2343.
2. Murone M, et al. Mol Cancer Ther. 2017 May 3. pii: molcanther.0889.2016.
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