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Deferoxamine

Chemical Structure : Deferoxamine

CAS No.: 70-51-9

Deferoxamine (Deferoxamine B, DFO)

Catalog No.: PC-25537Not For Human Use, Lab Use Only.

Deferoxamine (DFO) is a small molecule iron chelator and ferroptosis inhibitor, upregulates HIF-1α levels with good antioxidant activity, also shows anti-proliferative activity, can induce apoptosis and autophagy in cancer cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Deferoxamine (DFO) is a small molecule iron chelator and ferroptosis inhibitor, upregulates HIF-1α levels with good antioxidant activity, also shows anti-proliferative activity, can induce apoptosis and autophagy in cancer cells.

Physicochemical Properties

M.Wt 560.69
Formula C25H48N6O8
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N1-(5-Aminopentyl)-N1-hydroxy-N4-(5-(N-hydroxy-4-((5-(N-hydroxyacetamido)pentyl)amino)-4-oxobutanamido)pentyl)succinamide

References

1. Christophe Louandre, et al. Int J Cancer. 2013 Oct 1;133(7):1732-42.

2. Dongiovanni P, et al. Am J Pathol. 2008 Mar;172(3):738-47.

3. Wu Y, et al. Neurochem Int. 2010 Oct;57(3):198-205.

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