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Chemical Structure : Deleobuvir
Catalog No.: PC-60952Not For Human Use, Lab Use Only.
Deleobuvir (BI-207127, BI207127) is a potent, selective HCV NS5B polymerase inhibitor with IC50 of 50 nM against GT-1 HCV polymerase activity.
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Deleobuvir (BI-207127, BI207127) is a potent, selective HCV NS5B polymerase inhibitor with IC50 of 50 nM against GT-1 HCV polymerase activity.
Deleobuvir demonstrates subgenomic antiviral activity against GT1b and GT1a with EC50 of 11 and 23 nM in cell-based replicon assays.
Deleobuvir shows weak or no inhibition in specificity assays that include poliovirus RdRp, mammalian DdRp II, and DNA polymerase α, β, and γ.
Deleobuvir displays good antiviral potency and tolerability in early clinical trials of short-term treatment either as a single agent or in combination with pegylated IFN-α2a/ribavirin in HCV GT1 patients.
| M.Wt | 653.581 | |
| Formula | C34H33BrN6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zeuzem S, et al. Gastroenterology. 2011 Dec;141(6):2047-55; quiz e14.
2. Zeuzem S, et al. Antivir Ther. 2013;18(8):1015-9.
3. Larrey D, et al. Antimicrob Agents Chemother. 2013 Oct;57(10):4727-35.
4. LaPlante SR, et al. J Med Chem. 2014 Mar 13;57(5):1845-54.
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