Deoxygedunin | TrkB agonist | Probechem Biochemicals

Chemical Structure : Deoxygedunin

Deoxygedunin (14,15-deoxygedunin)

Catalog No.: PC-70344Not For Human Use, Lab Use Only.

Deoxygedunin is a naturally occurring tetranortriterpenoid that has been found to act as a potent, selective, small-molecule agonist of TrkB with Kd of 1.4 uM.

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Biological Activity

Deoxygedunin is a naturally occurring tetranortriterpenoid that has been found to act as a potent, selective, small-molecule agonist of TrkB with Kd of 1.4 uM.
Deoxygedunin activates TrkB in mouse brain in a BDNF-independent way.
Deoxygedunin prevents the degeneration of vestibular ganglion in BDNF -/- pups, and produces TrkB-dependent neurotrophic and neuroprotective effects in mice and enhances learning processes.

Physicochemical Properties

M.Wt	466.566
Formula	C28H34O6
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1R,4bR,5R,6aR,10aR,10bR,12aR)-5-(Acetyloxy)-1-(3-furanyl)-1,5,6,6a,7,10a,10b,11,12,12a-decahydro-4b,7,7,10a,12a-pentamethyl-3H-phenanthro[2,1-c]pyran-3,8(4bH)-dione

References

1. English AW, et al. Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16217-22.

2. Jang SW, et al. PLoS One. 2010 Jul 13;5(7):e11528.

3. Nie S, et al. Neuropharmacology. 2015 Dec;99:448-58.

Deoxygedunin (14,15-deoxygedunin)

Biological Activity

Physicochemical Properties

References

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