Chemical Structure : Desipramine
CAS No.:
50-47-5
Desipramine
Catalog No.: PC-28318Not For Human Use, Lab Use Only.
Desipramine is a tricyclic antidepressant that selectively blocks reuptake of norepinephrine from the neuronal synapse, also inhibits serotonin reuptake, also activates MAPK signaling via ERK1/2, JNK, and p38, represses NF-κB and AP-1 activity, and induces apoptosis via ROS elevation, mitochondrial membrane potential reduction, and intracellular calcium increase.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Desipramine is a tricyclic antidepressant that selectively blocks reuptake of norepinephrine from the neuronal synapse, also inhibits serotonin reuptake, also activates MAPK signaling via ERK1/2, JNK, and p38, represses NF-κB and AP-1 activity, and induces apoptosis via ROS elevation, mitochondrial membrane potential reduction, and intracellular calcium increase.
Physicochemical Properties
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M.Wt
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266.39
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Formula
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C18H22N2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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5H-Dibenz[b,f]azepine-5-propanamine, 10,11-dihydro-N-methyl-
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References
1. Ma J, et al. J Neurooncol. 2011 Jan;101(1):41-8.
2. Yang DK, et al. Oncol Rep. 2017;38(2):1029-1034.
4. Deupree JD, et al. Eur J Pharmacol. 2007;576(1-3):55-60.
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