Deulorlatinib (Lorlatinib-d3, TGRX-326) | ALK/ROS1 inhibitor

Chemical Structure : Deulorlatinib

Deulorlatinib (Lorlatinib-d3, TGRX-326, TGRX326)

Catalog No.: PC-24947Not For Human Use, Lab Use Only.

Deulorlatinib (Lorlatinib-d3) is a deuterated derivative of Lorlatinib (PF-06463922), a potent, CNS-penetrant, ATP-competitive inhibitor of ALK/ROS1.

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Biological Activity

Deulorlatinib (Lorlatinib-d3, TGRX-326, TGRX326) is a deuterated derivative of Lorlatinib (PF-06463922), a potent, CNS-penetrant, ATP-competitive inhibitor of ALK/ROS1.

Physicochemical Properties

M.Wt	409.44
Formula	C21H16D3FN6O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2H-4,8-Methenopyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile, 7-amino-12-fluoro-10,15,16,17-tetrahydro-10,16-dimethyl-2-(methyl-d3)-15-oxo-, (10R)-

References

1. Patent WO2017148325 A1.

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Deulorlatinib (Lorlatinib-d3, TGRX-326, TGRX326)

Biological Activity

Physicochemical Properties

References

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