Catalog No.: PC-62205Not For Human Use, Lab Use Only.
Diazepinomicin (TLN 4601, ECO-4601) is a brain penetrant inhibitor of Ras-RAF-MAPK pathway post Ras prenylation and prior to MEK activation, binds the central and/or peripheral benzodiazepine receptors (PBR, TSPO).
Diazepinomicin (TLN 4601, ECO-4601) is a brain penetrant inhibitor of Ras-RAF-MAPK pathway post Ras prenylation and prior to MEK activation, binds the central and/or peripheral benzodiazepine receptors (PBR, TSPO).
Diazepinomicin prevents EGF-induced phosphorylation of Raf-1, MEK, and ERK1/2.
Diazepinomicin reduces Ras-GTP levels and induces apoptosis.
Diazepinomicin shows antitumor activity and decreases tumor Raf-1 protein levels in MIA PaCa-2 tumor-bearing mice.
