Dibenzazepine | γ-secretase inhibitor

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Chemical Structure : Dibenzazepine

CAS No.: 209984-56-5

Dibenzazepine (YO-01027)

Catalog No.: PC-22490Not For Human Use, Lab Use Only.

Dibenzazepine (YO-01027, DBZ) is a potent γ-secretase inhibitor with IC50 values of 2.92 and 2.64 nM for Notch and APPL cleavage, respectively, exhibits potent inhibiting activity against SPP in vitro and in vivo through the interaction of Val223 in SPP.

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5 mg	$88	In stock
10 mg	$138	In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Physicochemical Properties

M.Wt	463.48
Formula	C26H23F2N3O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-(2-(3,5-Difluorophenyl)acetamido)-N-((S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propanamide

References

1. Groth C, et al. Mol Pharmacol. 2010 Apr;77(4):567-74.

2. Hirano J, et al. Proc Natl Acad Sci U S A. 2017 Dec 12;114(50):E10782-E10791.

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Dibenzazepine (YO-01027)

Biological Activity

Physicochemical Properties

References

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