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Chemical Structure : Dibenzazepine
CAS No.: 209984-56-5
Catalog No.: PC-22490Not For Human Use, Lab Use Only.
Dibenzazepine (YO-01027, DBZ) is a potent γ-secretase inhibitor with IC50 values of 2.92 and 2.64 nM for Notch and APPL cleavage, respectively, exhibits potent inhibiting activity against SPP in vitro and in vivo through the interaction of Val223 in SPP.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $138 | In stock | |
| 25 mg | $238 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | Get quote |
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Dibenzazepine (YO-01027, DBZ) is a potent γ-secretase inhibitor with IC50 values of 2.92 and 2.64 nM for Notch and APPL cleavage, respectively, exhibits potent inhibiting activity against SPP in vitro and in vivo through the interaction of Val223 in SPP.
| M.Wt | 463.48 | |
| Formula | C26H23F2N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-2-(2-(3,5-Difluorophenyl)acetamido)-N-((S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propanamide |
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1. Groth C, et al. Mol Pharmacol. 2010 Apr;77(4):567-74.
2. Hirano J, et al. Proc Natl Acad Sci U S A. 2017 Dec 12;114(50):E10782-E10791.
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