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Dickkopf inhibitor IIIC3

Chemical Structure : Dickkopf inhibitor IIIC3

CAS No.: 524-26-5

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Dickkopf inhibitor IIIC3 (Gallocyanine, NCI8642)

Catalog No.: PC-62022Not For Human Use, Lab Use Only.

NCI8642 (Gallocyanine, Dickkopf inhibitor IIIC3) is a small-molecule inhibitor of Wnt antagonist Dickkopf with EC50 of 5 uM for reversing DKK1 CM-mediated Wnt inhibition.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    NCI8642 (Gallocyanine, Dickkopf inhibitor IIIC3) is a small-molecule inhibitor of Wnt antagonist Dickkopf with EC50 of 5 uM for reversing DKK1 CM-mediated Wnt inhibition.
    NCI8642 (Gallocyanine, Dickkopf inhibitor IIIC3) inhibits the binding of DKK1-alkaline phosphatase (AP) to HEK293 cells expressing the wild-type LRP5 or LRP5 mutant with IC50 of 3 uM.
    NCI8642 (Gallocyanine, Dickkopf inhibitor IIIC3) reduces basal blood-glucose concentrations and improves glucose tolerance in mice.

    Physicochemical Properties

    M.Wt 300.27
    Formula C15H12N2O5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    7-(dimethylamino)-4-hydroxy-3-oxo-3H-phenoxazine-1-carboxylic acid

    References

    1. Li X, et al. Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11402-7.

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