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Diclofensine

Chemical Structure : Diclofensine

CAS No.: 67165-56-4

Diclofensine (Ro 8-4650)

Catalog No.: PC-45481Not For Human Use, Lab Use Only.

Diclofensine (Ro 8-4650) is an antidepressant that acts as a triple monoamine reuptake inhibitor.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Diclofensine (Ro 8-4650) is an antidepressant that acts as a triple monoamine reuptake inhibitor.
Diclofensine blocks the uptake of dopamine, noradrenaline, and serotonin by rat brain synaptosomes with IC50 of 0.74, 2.3, and 3.7 nM, respectively.
Diclofensine increases locomotor activity, decreases food intake, and has abuse potential.

Physicochemical Properties

M.Wt 322.229
Formula C17H17Cl2NO
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Isoquinoline, 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-7-methoxy-2-methyl-

References

1. Keller HH, et al. Adv Biochem Psychopharmacol. 1982;31:249-63.

2. Tirelli E, et al. J Pharmacol Exp Ther. 1998 Jan;284(1):116-24.

3. Jackson SH, et al. Br J Clin Pharmacol. 1983 Oct;16(4):427-9.

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