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Diclofensine

Chemical Structure : Diclofensine

CAS No.: 67165-56-4

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Diclofensine (Ro 8-4650)

Catalog No.: PC-45481Not For Human Use, Lab Use Only.

An antidepressant that acts as a triple monoamine reuptake inhibitor.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

An antidepressant that acts as a triple monoamine reuptake inhibitor; blocks the uptake of dopamine, noradrenaline, and serotonin by rat brain synaptosomes with IC50 of 0.74, 2.3, and 3.7 nM, respectively; increases locomotor activity, decreases food intake, and has abuse potential.

Physicochemical Properties

M.Wt 322.229
Formula C17H17Cl2NO
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Isoquinoline, 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-7-methoxy-2-methyl-

References

1. Keller HH, et al. Adv Biochem Psychopharmacol. 1982;31:249-63.

2. Tirelli E, et al. J Pharmacol Exp Ther. 1998 Jan;284(1):116-24.

3. Jackson SH, et al. Br J Clin Pharmacol. 1983 Oct;16(4):427-9.

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