Chemical Structure : Diclofensine
CAS No.: 67165-56-4
Catalog No.: PC-45481Not For Human Use, Lab Use Only.
Diclofensine (Ro 8-4650) is an antidepressant that acts as a triple monoamine reuptake inhibitor.
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Diclofensine (Ro 8-4650) is an antidepressant that acts as a triple monoamine reuptake inhibitor.
Diclofensine blocks the uptake of dopamine, noradrenaline, and serotonin by rat brain synaptosomes with IC50 of 0.74, 2.3, and 3.7 nM, respectively.
Diclofensine increases locomotor activity, decreases food intake, and has abuse potential.
M.Wt | 322.229 | |
Formula | C17H17Cl2NO | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
Isoquinoline, 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-7-methoxy-2-methyl- |
1. Keller HH, et al. Adv Biochem Psychopharmacol. 1982;31:249-63.
2. Tirelli E, et al. J Pharmacol Exp Ther. 1998 Jan;284(1):116-24.
3. Jackson SH, et al. Br J Clin Pharmacol. 1983 Oct;16(4):427-9.
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