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Diclofensine hydrochloride

Chemical Structure : Diclofensine hydrochloride

CAS No.: 34041-84-4

Diclofensine hydrochloride (Ro 8-4650 hydrochloride)

Catalog No.: PC-45480Not For Human Use, Lab Use Only.

Diclofensine (Ro 8-4650) hydrochloride is an antidepressant that acts as a triple monoamine reuptake inhibitor.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Diclofensine (Ro 8-4650) hydrochloride is an antidepressant that acts as a triple monoamine reuptake inhibitor.
Diclofensine blocks the uptake of dopamine, noradrenaline, and serotonin by rat brain synaptosomes with IC50 of 0.74, 2.3, and 3.7 nM, respectively.
Diclofensine increases locomotor activity, decreases food intake, and has abuse potential.

Physicochemical Properties

M.Wt 358.6899
Formula C17H18Cl3NO
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

H2O: ≥ 52 mg/mL

Chemical Name/SMILES

Isoquinoline, 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-7-methoxy-2-methyl-, hydrochloride (1:1)

References

1. Keller HH, et al. Adv Biochem Psychopharmacol. 1982;31:249-63.

2. Tirelli E, et al. J Pharmacol Exp Ther. 1998 Jan;284(1):116-24.

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