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Difamilast

Chemical Structure : Difamilast

CAS No.: 937782-05-3

Difamilast (OPA-15406, OPA15406)

Catalog No.: PC-61372Not For Human Use, Lab Use Only.

Difamilast (OPA-15406) is a novel potent, selective phosphodiesterase IV (PDE4) inhibitor with preference for PDE4B (IC50=11.2 nM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Difamilast (OPA-15406) is a novel potent, selective phosphodiesterase IV (PDE4) inhibitor with preference for PDE4B (IC50=11.2 nM). 

Physicochemical Properties

M.Wt 446.451
Formula 3H24F2N2O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-({2-[4-(difluoromethoxy)-3-(propan-2-yloxy)phenyl]-1,3-oxazol-4-yl}methyl)-2-ethoxybenzamide

References

1. Hanifin JM, et al. J Am Acad Dermatol. 2016 Aug;75(2):297-305.

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