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Difelikefalin

Chemical Structure : Difelikefalin

CAS No.: 1024828-77-0

Difelikefalin (CR845, CR-845, FE-202845)

Catalog No.: PC-23828Not For Human Use, Lab Use Only.

Difelikefalin (CR-845; FE-202845) is a potent, selective and peripherally-restricted kappa opioid receptor (KOR) agonist, prevents [3H]diprenorphine binding to KOR with IC50 of 1.16 nM, and binding Kd of 0.23 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Difelikefalin (CR-845; FE-202845) is a potent, selective and peripherally-restricted kappa opioid receptor (KOR) agonist, prevents [3H]diprenorphine binding to KOR with IC50 of 1.16 nM, and binding Kd of 0.23 nM.

Physicochemical Properties

M.Wt 679.86
Formula C36H53N7O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-Piperidinecarboxylic acid, N1-(D-phenylalanyl-D-phenylalanyl-D-leucyl-D-lysyl)-4-amino-

References

1. Viscusi ER, et al. Clin Transl Sci. 2021 Sep;14(5):1886-1893.

2. Wang X, et al. Front Pharmacol. 2021 Nov 16;12:773204.

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