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Difluorophenyl Quinazoline

Chemical Structure : Difluorophenyl Quinazoline

CAS No.: 911678-60-9

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Difluorophenyl Quinazoline (DFPQ, AP-06-202)

Catalog No.: PC-20987Not For Human Use, Lab Use Only.

Difluorophenyl Quinazoline (DFPQ, AP-06-202) is a selective, biased, negative allosteric modulator of β-arrestin recruitment to the β2AR, without effect on on β2AR coupling to Gs.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Difluorophenyl Quinazoline (DFPQ, AP-06-202) is a selective, biased, negative allosteric modulator of β-arrestin recruitment to β2-adrenergic receptor (β2AR), without effect on on β2AR coupling to Gs.
DFPQ effectively inhibits agonist-promoted phosphorylation and internalization of the β2AR and protects against the functional desensitization of β-agonist mediated regulation in cell and tissue models.
Difluorophenyl Quinazoline (DFPQ) also is specific to the β2AR with minimal effects on the β1AR.

Physicochemical Properties

M.Wt 354.40
Formula C20H20F2N4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

FC1=CC=C(NC2=NC(NC3CCCCC3)=C4C=CC=CC4=N2)C=C1F

References

1. Ippolito M, et al. Proc Natl Acad Sci U S A. 2023 Aug;120(31):e2302668120.

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