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Chemical Structure : Dihydrotanshinone I
Catalog No.: PC-60913Not For Human Use, Lab Use Only.
A natural product that prevents HuR/RNA complex formation with Ki of 3.74 nM.
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A natural product that prevents HuR/RNA complex formation with Ki of 3.74 nM; influences mRNA stability and translational efficiency of TNF in a HuR-dependent manner and also other functional readouts of its post-transcriptional control, such as the stability of selected pre-mRNAs in breast cancer cell lines; disrupts HuR multimerization modules and reduces tumor cell survival and proliferation, potently inhibits xenograft tumor growth in a HuR-dependent model without systemic toxicity in vivo.
| M.Wt | 278.3 | |
| Formula | C18H14O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. D'Agostino VG, et al. Sci Rep. 2015 Nov 10;5:16478.
2. Park JW, et al. Arch Pharm Res. 2008 Jan;31(1):47-53.
3. Filippova N, et al. J Biol Chem. 2017 Oct 13;292(41):16999-17010.
4. Lal P, et al. Nucleic Acids Res. 2017 Sep 19;45(16):9514-9527.
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