Chemical Structure : Diltiazem hydrochloride
CAS No.:
33286-22-5
Diltiazem hydrochloride
(CRD-401)
Catalog No.: PC-44015Not For Human Use, Lab Use Only.
Diltiazem hydrochloride (CRD-401) is a postsynaptic muscle relaxant that inhibits Ca2+ ions release from sarcoplasmic reticulum stores, inhibits L-type voltage-dependent Ca2+ channels (L-VDCC).
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Purity & Documentation Purity:
>98% (HPLC)
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Biological Activity
Diltiazem hydrochloride (CRD-401) is a postsynaptic muscle relaxant that inhibits Ca2+ ions release from sarcoplasmic reticulum stores, inhibits L-type voltage-dependent Ca2+ channels (L-VDCC).
Diltiazem hydrochloride (CRD-401) antagonizes ryanodine receptors (RyR).
Diltiazem hydrochloride (CRD-401) can prevent cell death in neural progenitor cells derived from Wolfram syndrome iPS cells.
Physicochemical Properties
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M.Wt
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450.9788
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Formula
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C22H27ClN2O4S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-, hydrochloride (1:1), (2S,3S)-
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References
1. Lu S, et al. Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):E5292-301.
2. Zucchi R, et al. Pharmacol Rev. 1997 Mar;49(1):1-51.
3. Krause T, et al. Anaesthesia. 2004 Apr;59(4):364-73.
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