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Chemical Structure : Diphyllin
CAS No.: 22055-22-7
Catalog No.: PC-63544Not For Human Use, Lab Use Only.
Diphyllin is a naturally potent vacuolar ATPase (v-ATPase) inhibitor with IC50 of 17 nM, potently inhibits the acid influx with IC50 of 0.6 nM.
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Diphyllin is a naturally potent vacuolar ATPase (v-ATPase) inhibitor with IC50 of 17 nM, potently inhibits the acid influx with IC50 of 0.6 nM.
Diphyllin dose-dependently inhibits lysosomal acidification in human osteoclasts, inhibits human osteoclastic bone resorption (IC50=14 nM), calcium release, and pit area, despite increasing TRACP activity, numbers of osteoclasts, and cell viability.
Diphyllin also inhibits the proliferation and induce the apoptosis of human gastric cancer cells.
Diphyllin shows potential antiviral for various influenza virus strains using cell-based assays, through the inhibition of endosomal acidification, thus interfering with downstream virus replication.
| M.Wt | 380.352 | |
| Formula | C21H16O7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Naphtho[2,3-c]furan-1(3H)-one, 4-hydroxy-6,7-dimethoxy-9-[3,4-(methylenedioxy)phenyl]- (8CI) |
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1. Sørensen MG, et al. J Bone Miner Res. 2007 Oct;22(10):1640-8.
2. Di Giorgio C, et al. Planta Med. 2005 Apr;71(4):366-9.
3. Shen W, et al. Eur J Pharmacol. 2011 Sep 30;667(1-3):330-8.
4. Chen HW, et al. Antiviral Res. 2013 Sep;99(3):371-82.
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